I can't get into any of the comedy/cute Anime. My favorite by a mile was Berserk. I also enjoyed the first half of Blue Gender, X: The Movie, Vampire Hunter D 1 and 2, Blood: The Last Vampire, and both Ghost in the Shell Movies. See Casshan on Sci-Fi on Saturday mornings is what got me into Anime, so it will always have a soft spot.
I'm very sporadic in my viewing, but I'm currently rotating between: Ergo Proxy, GITS:SAC, Gasaraki, Claymore, Monster, and Night Head Genesis. Just depends on what I'm in the mood for.